RNA Details
Disease Name
diabetic nephropathy
Tissue
kidney
RNA Symbol
mir-135a-1
RNA ID
RNA Type
miRNA
Alteration Pattern
up regulation
Species
homo sapiens
Detection Methods
qRT-PCR; dual-luciferase reporter assay
Target
SIRT1
Pathway
TGF-BETA SIGNALING PATHWAY
PubMed ID
Title
Inhibition of miRNA-135a-5p ameliorates TGF-beta1-induced human renal fibrosis by targeting SIRT1 in diabetic nephropathy
Year
2020
Function
Knockdown of miR-135a-5p inhibits TGF-beta1-induced renal fibrosis by targeting sirt1 and inactivating smad3 signaling.